Composition

Purified Water, Hydroxypropyl Methylcellulose, Benzyl Alcohol, Prezatide Copper Acetate (PCA), Sodium Chloride.

Indications

A hydrogel for the dressing and management of lick granulomas, acute or chronic wounds and dermatological disorders, including partial and full-thickness wounds, skin ulcerations, pressure sores, burns, postoperative incisions, suture line dehiscence, fistulas, cuts, puncture wounds, abrasions, and other general dermatologic conditions.

Actions

Iamin-Vet Skin Care Gel provides an improved healing environment for wounds and dermatological disorders. Iamin-Vet Skin Care Gel contains copper, which is complexed to the peptide glycyl-L-histidyl-L-lysine (GHK) to form prezatide copper acetate (PCA). GHK is a naturally occurring peptide found in several biological fluids, including plasma. A synthetic form of GHK, used in the preparation of the copper complex, acts as a controlled delivery system for copper to the wound site. It is well established that copper is essential for many important functions in the body, including wound healing. Normal wound healing is a cascade of events which involves the interaction of various cell types in an organized manner. It is generally characterized by three stages of healing: the inflammation phase, the proliferation phase, and the regeneration phase.

PCA has been shown to enhance tissue repair through 1) attraction of multiple cell types (macrophages, monocytes and mast cells) to the wound site, 2) introduction of new capillary growth, and 3) stimulation of granulation tissue formation. Nonclinical studies in experimentally wounded rats and pigs have shown a significant increase in the rate of formation of extracellular matrix components (e.g., collagen and proteoglycans) following PCA treatment when compared to controls. Topical treatment with a PCA containing gel also has been shown to significantly accelerate the rate of wound closure in experimentally created dermal wounds in dogs when compared to either vehicle or untreated wounds.(2)

Previous Clinical Experience

The Iamin-Vet Skin Care Gel technology has been scientifically and medically documented in animal and human studies and has been detailed in numerous peer-reviewed journal articles. PCA has been tested in a number of wound or skin-related applications including full or partial-thickness lesions of the skin, skin ulcerations, suture line dehiscence, fistulous tracts, and skin irritations and eruptions. Primary findings include reduction of inflammation which accompanies infection, formation of a natural protective barrier, enhancement of vascularization and granulation tissue formation, and acceleration of wound contraction and epithelialization. In most cases, results were observed in clinical conditions which previously had been unresponsive to standard therapy.

Adverse Reactions

Iamin-Vet Skin Care Gel has been evaluated for safety using standard biocompatibility testing methods, and has been found to be safe to use as indicated. Adverse effects have not been encountered with topically applied Iamin-Vet Skin Care Gel. The copper content in this product is well below the level associated with induction of systemic or organ toxicity.

Precautions and Warnings

Iamin-Vet Skin Care Gel should not be used as a primary treatment for ongoing infections. In case of persistent inflammation, consult your veterinarian and discontinue treatment. In the case of deep wounds or serious burns, use only as recommended by a veterinarian. Emesis could occur in dogs if greater than 90 grams of Iamin-Vet Skin Care Gel are ingested. Each tube of Iamin-Vet Skin Care Gel should be used by one animal only in order to reduce the risk of cross infection.

Dosage and Administration

As needed, first debride and cleanse the wound with a suitable wound cleanser. Apply Iamin-Vet Skin Care Gel to sufficiently cover the entire area of the wound. The severity of the wound or disruption of the skin will determine the frequency of administration. Iamin-Vet Skin Care Gel can be applied to the affected area with or without a dressing, up to four times per day. As the wound or dermatologic disorder improves, Iamin-Vet Skin Care Gel applications are required less frequently. When dressings are required, best results may be obtained using non- or semi-occlusive materials. If sterile gauze is used as an overdressing, it may be moistened. Application to minor skin abrasions, irritations, or rashes may best be accomplished by gently massaging the gel into the affected area. Typically, a partial-thickness wound of approximately 20 sq. cm. wound will require 1 to 2 c.c. (about 1-2 grams) per application. Iamin-Vet Skin Care Gel may be used in combination with a topical or systemic antibiotic.

Contraindications

While beneficial to most wounds and skin conditions, Iamin-Vet Skin Care Gel may be contraindicated in typically hyper-granulating wounds such as lower limb wounds in horses.

Storage

Store at room temperature. Do not freeze.

How Supplied

Iamin-Vet Skin Care Gel is available in 15 gram (0.5 oz) and 90 gram (3 oz) sizes.

References

1. Milne, D. B. Clinical Chemistry News, July 1993

2. Swaim, S. F., D. M. Bradley, J. S. Spano, J. A. McGuire, C. E. Hoffman, and R. E. Trachy. J. Am. Anim. Hosp. Assoc., 1993

Large Animal Results

Partial-Thickness Wounds/Burns: A five-month-old miniature horse had two partial-thickness wounds located on the dorsal midline. The wounds had persisted for 5 weeks with minimal improvement in condition or healing. At the time of initiating treatment with Iamin®-Vet Skin Care Gel, the caudal wound measured 6 x 15 cm (tear-shaped), and the cranial wound measured approximately 3 cm in diameter. The beginning of re-epithelialization was evident by treatment Day 4. The cranial wound was clinically healed by Day 11 with an excellent appearance. The larger caudal wound was completely healed via re-epithelialization by Day 27 with no scar.

A thirteen-year old gelding sustained a severe rope burn which removed all skin from an area just above the rear hoof. The wound was kept clean and treated with Furacin® ointment. The wound was inflamed and caused the horse discomfort when walking. Over a period of ten days, the owner felt that the wound was not responding to the Furacin® treatment. Iamin®-Vet Skin Care Gel treatment was begun and, within a few days, the area developed a healthy appearing scab and evidence of epithelialization around the periphery. The wound healed totally within 3 weeks.

Full-Thickness Wounds: A yearling Arabian filly developed an infected wound involving the flexor tendon sheath. After surgical debridement, the wound was 3.4 cm in diameter an 1.3 cm deep. Treatment with Iamin®-Vet Skin Care Gel was initiated immediately after the surgery in order to encourage granulation of the wound. Within 3 days of treatment, the lesion was filling rapidly with granulation tissue. Treatment was discontinued at that time in order to limit potential proud flesh accumulation. An excellent post-operative result was achieved.

A thoroughbred mare sustained an injury to the chest which resulted in a V-shaped skin flap about 10 cm on each side. Healing appeared to progress normally for about two weeks. After a third week in which little further progress was noted, a daily wash with hydrogen peroxide followed by treatment with Iamin®-Vet Skin Care Gel was initiated. Wound size began to rapidly decrease and, by Day 4, the wound measured 4 cm on each side. By Day 11, the wound was 1.5 x 0.5 cm. Total wound healing was anticipated when the horse was released to the owner.

Fistula: An adult female llama developed an actively draining fistula tract on the left side of the abdomen. Exploratory surgery was performed, resulting in two wounds of 8 and 10 cm in diameter. Perforated surgical tubing connecting the two wounds was left in place and the wounds were flushed with povidone iodine twice daily. Six days post surgery, the tubing was removed and treatment with Iamin®-Vet gel commenced. After 2 treatments, there was a noticeable of granulation tissue which was filling in the fistula. Continued treatment with Iamin®-Vet Skin Care Gel resulted in reduction of the dorsal wound opening to approximately 2 cm, and complete closure of the ventral opening by Day 18. Treatment was discontinued due to the difficulty of working with this animal resulting in subsequent reopening of the fistula tract, and the animal was sent for surgical evaluation. The treating veterinarian was very impressed with the excellent response observed with the Iamin®-Vet Skin Care Gel treatment and felt the wound would have totally healed with continued treatment.

Lacerations: An older Arabian mare was examined for vaginal bleeding. A laceration measuring 2.5 by 1.0 cm was found of undetermined origin in the roof of the vaginal vault. Treatment with Iamin®-Vet Skin Care Gel was begun (1 time / day ) for 3 days. The laceration reduced in size by approximately 75% by Day 3, at which time the animal was switched to an anti-hemorrhoidal ointment to control serum seepage from varicose veins. Iamin®-Vet Skin Care Gel was discontinued at that time. The veterinarian treating this animal was impressed with the rapid closure of the laceration and the relative ease of treatment.

A six-month-old thoroughbred received extensive injuries to its front legs and chest area after running through a barbed wire fence. These wounds failed to respond to systemic antibiotics administered by a veterinarian, and remained open and infected after 2 weeks of therapy. One wound was very deep with purulent drainage. Treating this wound twice daily with Iamin®-Vet Skin Care Gel eliminated the infection within a few days. Granulation tissue filled the wound and a scab formed a short time later. After approximately 3 weeks, the wound was totally healed via contraction, leaving only a small residual scar.

A thirteen year old quarter horse received a 3 cm long laceration to the anterior aspect of the right upper leg. Veterinary treatment involved opening the wound to allow drainage, Furacin® spray treatment for 1 week, and a course of systemic antibiotics for 1 week. The wound continued to be inflamed and swollen with a purulent drainage. Treatment twice daily for 12 days with Iamin®-Vet Skin Care Gel resulted in closure of the wound with a small residual surface scab. There was no indication of residual inflammation or sensitivity. Treatment was continued (once per day) for 7 days. By Day 28, the wound was totally closed with only a small residual scar.

Features and Benefits

• New Hydropolymer Technology
• Over 50 ml Capacity
• Cushions & Eliminates Maceration
• Up to 7 days Between Dressing Changes
• Proper Moisture Control Helps Wound Healing

With superior volume capacity, OsmoCyte Pillow Dressing easily outperforms leading absorptive dressings!

Indications

OsmoCyte™ Pillow Wound Dressings are ideal for moisture management of highly exudating wounds and dermatological disorders. OsmoCyte™ Pillows can be used on infected and non-infected wounds and can be used with Iamin®-Vet Skin Care Gel and/or antibiotics.

• Pressure Ulcers
• Bleeding Surface Wounds
• Dermal Lesions
• Trauma Injuries 1st and 2nd Degree Burns
• Drain Sites
• Post-operative Incisions
• Fistulas

Administration

• Irrigate wound site with saline or other suitable wound cleanser.
• Apply dressing to a moist wound surface.
• Cover with an appropriate secondary dressing; secure in place.
• Dressing changes depend on the quantity of exudate and the condition of the wound.
• Dressings should be changed when saturated or at least every 7 days, with more frequent changes for infected wounds.
• Should infection of the wound site occur, appropriate antibiotic therapy should be started and the wound carefully monitored.

Veterinary Products Ordering Information

Iamin-Vet Skin Care Gel
For more information or to order contact our Customer Service department or call toll free 1-888-966-1010

Product	Size	Product No.	Quantity
Iamin-Vet Skin Care Gel	15 gm tube	IM015V	24 boxes/case
Iamin-Vet Skin Care Gel	90 gm tube	IM090V	12 boxes/case

Iamin-Vet Wound Cleanser
For more information or to order contact our Customer Service department or call toll free 1-888-966-1010

Product	Size	Product No.	Quantity
Iamin-Vet Wound Cleanser	8 oz. spray bottle	IM008	6/case

OsmoCyte-Vet Pillow Wound Dressing
For more information or to order contact our Customer Service department or call toll free 1-888-966-1010

Product	Size	Product No.	Dressings / Box	Boxes / Case
OsmoCyte Pillow Wound Dressing	0.75" x 6"	OS016V	10	10
OsmoCyte Pillow Wound Dressing	1.5" x 3"	OS013V	10	10
OsmoCyte Pillow Wound Dressing	3" x 3"	OS033V	10	5
OsmoCyte Pillow Wound Dressing	4" x 4"	OS044V	10	5